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Table 3 Sensitivity and positive predictive value with different tumor size change cut-offs

From: Are tumor size changes predictive of survival for checkpoint blockade based immunotherapy in metastatic melanoma?

Survive Additional t (years) from Week 12

+ 20%

−10%

−30%

Sensitivity

PPV

Sensitivitya

PPVb

Sensitivity

PPV

1

92.7%

82.6%

65.4%

87.1%

48.6%

91.0%

2

93.8%

66.2%

71.2%

75.6%

55.3%

82.8%

3

94.9%

57.6%

76.0%

69.1%

60.8%

77.7%

  1. aSensitivity: Prob (tumor size change “<= −10%” at Week 12 given surviving additional t years)
  2. bPositive Predictive Value (PPV): Prob(survive additional t years given tumor size change “<= − 10%” at Week 12)