Fig. 1
Patients are numbered the same in all inserts (also the same as in Table 1) and are ordered by study arm. a Changes in FLT SUVmean in vaccine draining left axillary lymph nodes are shown for each patient along with changes in non-draining right axillary lymph nodes. A number of outliers with changes in left axillary lymph node SUVmean greater than 50% are evident. b Representative FLT PET/CT slice is showing a vaccine draining left axillary lymph with elevated uptake after 12 weeks of therapy (patient #1) c Changes in SUVmean in bone marrow and spleen. d Representative FLT PET/CT slice is showing increased splenic FLT uptake after 12 weeks (patient #17). e Changes in FLT uptake in patients with soft tissue metastases are shown for SUVmean and SUVtotal. Changes in tumor SUVmean and tumor SUVtotal were significantly correlated (ρ = 0.66, P = 0.04). f Representative FLT PET/CT slice is showing metastatic mediastinal lymph nodes with visually increased FLT uptake after 12 weeks of therapy (patient #9). Following RECIST guidelines this patient had radiographically stable disease at week 12 but had subsequent disease progression upon the next radiographic follow-up at 24 weeks. g Changes in thyroid FLT uptake h Representative PET/CT slice is shown for a patient that experienced grade 2 hyperthyroidism (patient #11). The arrow indicates the position of the right thyroid lobe where visually increased FLT uptake is evident at 12 weeks. Notably, this patient had their first pembrolizumab injection 1 day prior to their 12-week PET scan