Fig. 6
From: HDAC6 selective inhibition of melanoma patient T-cells augments anti-tumor characteristics
ACY-1215 Augments T-cell Cytotoxicity. T-cells from melanoma patient PBMC were expanded with DMSO, 500nM ACY-1215 or 500nM ACY-241, washed, then co-cultured with CFSE-labeled, irradiated allogeneic PBMC (target cells). (a) The numbers of viable target cells after co-culture are shown in a representative sample from one patient cultured at the indicated ratios (T-effector:Target) (triplicates assessed) and (b) in paired analyses of DMSO versus ACY-1215 and DMSO versus ACY-241 at 1:5 T-effector:Target ratio. Data are from six patient samples evaluated in two experiments. Error bars are +SEM. *p < 0.05, ***p < 0.001, ****p < 0.0001