Antibodies as biomarker candidates for response and survival to checkpoint inhibitors in melanoma patients

Table 1 Patient characteristics and outcome, cohort 1

Patient	Response	Characteristics (m¹/f²; age (y³))	Phototype	Histological type	BRAF Status (wt⁵/mut⁶)	Checkpoint inhibitor therapy	Number of involved organs	Metastasis	ECOG⁹ Performance status	Tumor Response at first CT scan¹⁰
1	Responders	m, 70	2	SSM⁴	mut	anti-PD1⁷	2	Lung, Lymph nodes	0	PR
2		m, 70	3	SSM	wt	anti-PD1	3	Soft tissue, Bone, Liver	0–1	SD*
3		f, 78	2	SSM	wt	anti-PD1 + anti-CTLA4⁸	3	Soft tissue, Lymph nodes, Lung	0	PR
4		m, 63	3	SSM	wt	anti-PD1	1	Lung	0	PR
5		m, 52	3	SSM	mut	anti-PD1 + anti-CTLA4	4	Mesenterium, Peritoneum, Retroperitoneum, Brain	0	SD*
6		m, 86	3	nodular	wt	anti-PD1	2	Bone, Lung	0	PR
7		f, 66	2	nodular	mut	anti-CTLA4	5	Lymph nodes, Lung, Soft tissue, Suprarenal gland, Stomach	0	PR
8		f, 81	2	nodular	wt	anti-PD1	5	Lymph node, Soft tissue, Lung, Bone, Liver	0	PR
9		f, 66	2	nodular	wt	anti-PD1	3	Soft tissue, Lymph nodes, Brain	0	PR
10		m, 78	2	nodular	wt	anti-PD1	3	Soft Tissue, Lymph nodes, Lung	0	CR
11		f, 61	1	uveal	wt	anti-PD1	1	Bone	0	PR
12		m, 66	2	mucosal	wt	anti-PD1	6	Soft tissue, Lung, Pankreas, Small pelvis, Liver, Bone	0	PR
13	Non-Responders	m, 62	2	SSM	wt	anti-PD1	4	Suprarenal gland, Lung, Lymph node, Brain	0	SD
14		f, 56	2	SSM	mut	anti-PD1 + anti-CTLA4	5	Lung, Lymph node, Soft tissue, Liver, Stomach	1	PD
15		f, 87	3	nodular	mut	anti-PD1	5	Lung, Lymph node, Liver, Bone, Brain	1	SD
16		f, 71	2	uveal	wt	anti-CTLA4	3	Lung, Liver, Brain	0	PD
17		f, 71	2	uveal	wt	anti-PD1	2	Liver, Lymph node	0	SD
18		f, 87	2	mucuosal	wt	anti-PD1	1	Soft tissue	1	PD
19		f, 71	2	unknown, amelanotic	wt	anti-PD1	3	Lung, Lymph node, Suprarenal gland	0	SD
20		m, 72	3	unknown	wt	anti-PD1	7	Lung, Liver, Lymph node, Suprarenal gland, Pankreas, Bone, Eye muscle	0	PD

* pseudoprogression, ¹ male, ² female, ³ years, ⁴ superficial spreading melanoma, ⁵ wild type, ⁶ V600E mutation, ⁷ anti-programmed-cell-death protein-1, ⁸anti-cytotoxic-T-lymphocyte-associated-protein-4, ⁹Eastern Cooperative Oncology Group,¹⁰ CR Complete Remission, PR Partial Remission, SD Stable Disease, PD Progressive Disease