Fig. 1

T-cell subset frequencies in LN-, LN+ and PT of patients with CxCa. a Frequencies of CD4⁺ and CD8⁺ T cells. b Frequencies of CD8⁺ central memory (Tcm, CD27⁺CD45RA⁻), effector memory (Tem, CD27⁻CD45RA⁻), and effector (Temra, CD27⁻CD45RA⁺) T cells. c Left panel: frequencies of naïve (nCD4⁺, FoxP3⁻CD45RA⁺), F⁻CD4⁺ (FoxP3⁻CD45RA⁻) and F⁺aCD4⁺ (FoxP3^intCD45RA⁻) conventional CD4⁺ T cells. Right panel: frequencies of activated (aCD4⁺Tregs, FoxP3^hiCD45RA⁻) and resting regulatory T cells (rCD4⁺Tregs, FoxP3^intCD45RA⁺). d Frequencies of CD8⁺FoxP3⁺CD25⁺ T cells. Error bars represent standard error of the mean. LN-: n = 12–14, LN+: n = 12–14, PT: n = 9–10. *P = 0.01 to 0.05, **P = 0.001 to 0.01, ***P = 0.001 to 0.0001, ****P < 0.0001