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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Efficacy of PD-1 blockade in cervical cancer is related to a CD8+FoxP3+CD25+ T-cell subset with operational effector functions despite high immune checkpoint levels

Fig. 1

T-cell subset frequencies in LN-, LN+ and PT of patients with CxCa. a Frequencies of CD4+ and CD8+ T cells. b Frequencies of CD8+ central memory (Tcm, CD27+CD45RA), effector memory (Tem, CD27CD45RA), and effector (Temra, CD27CD45RA+) T cells. c Left panel: frequencies of naïve (nCD4+, FoxP3CD45RA+), FCD4+ (FoxP3CD45RA) and F+aCD4+ (FoxP3intCD45RA) conventional CD4+ T cells. Right panel: frequencies of activated (aCD4+Tregs, FoxP3hiCD45RA) and resting regulatory T cells (rCD4+Tregs, FoxP3intCD45RA+). d Frequencies of CD8+FoxP3+CD25+ T cells. Error bars represent standard error of the mean. LN-: n = 12–14, LN+: n = 12–14, PT: n = 9–10. *P = 0.01 to 0.05, **P = 0.001 to 0.01, ***P = 0.001 to 0.0001, ****P < 0.0001

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