Efficacy of PD-1 blockade in cervical cancer is related to a CD8+FoxP3+CD25+ T-cell subset with operational effector functions despite high immune checkpoint levels

Table 1 Clinical and pathological characteristics of the study population

Clinical characteristics	LN- (n = 14)	LN+ (n = 13)	PT (n = 10)
Age, mean ± SD	42,7 ± 9,5	47,6 ± 16,4	41,9 ± 12,1
FIGO stage
IB1	6 (42)	2 (15)	7 (70)
IB2	3 (22)	2 (15)	2 (20)
IIA2	1 (7)	1 (8)	1 (10)
IIB	3 (22)	6 (47)	0
IIIB	1 (7)	2 (15)	0
Histology
SCC	13 (93)	11 (85)	10 (100)
ASCC	1 (7)	2^a (15)	0
Vaginal involvement
Yes	0	2 (15)	1 (10)
No	11 (79)	10 (77)	9 (90)
Unknown	3 (21)	1 (8)	0
Parametrium invasion
Yes	6 (43)	10 (77)	0
No	7 (50)	3 (23)	10 (100)
Unknown	1 (7)	0	0
HPV-type
6	0	1 (8)	0
16	7 (50)	7 (53)	5 (50)
18	1 (7)	2 (15)	0
31	1 (7)	0	0
33	0	1 (8)	1 (10)
59	0	0	1 (10)
Unknown	4 (29)	1 (8)	2 (20)
p16+	1 (7)	–	1 (10)
Negative	0	1 (8)	0

Values in the table expressed as n (%) ^a Two tumor-positive lymph nodes were collected from the same patient. Abbreviations: LN- tumor-negative lymph nodes, LN+ tumor-positive lymph node, FIGO International Federation of Gynecology and Obstetrics, SCC squamous cell carcinoma, ASCC adenosquamous cell carcinoma, HPV human papillomavirus, PT primary tumor