Table 2 Cox proportional-hazards regression: univariate and multivariate analyses of Time to Treatment Failure

BMI

≥ 25 vs < 25

0.51 (0.44–0.60); p < 0.0001

0.67 (0.53–0.85); p = 0.0009

Weight^a

0.98 (0.97–0.99); p < 0.0001

0.99 (0.98–1.01); p = 0.8422

irAEs of any grade

Yes vs No

0.57 (0.48–0.66); p < 0.0001

0.79 (0.65–0.97); p = 0.0295

Primary Tumor (NSCLC)

 Melanoma

 Kidney

 Others

0.62 (0.50–0.76); p < 0.0001

0.73 (0.59–0.92); p = 0.0077

1.15 (0.71–1.87); p = 0.5560

0.79 (0.64–1.01); p = 0.0517

0.71 (0.56–0.88); p = 0.0025

0.78 (0.48–1.28); p = 0.3389

Sex

Male vs Female

1.22 (1.04–1.43); p = 0.0147

1.10 (0.93–1.30); p = 0.2607

Age

Elderly vs Non-elderly

1.04 (0.90–1.21); p = 0.5366

–

Treatment line

Non-first vs First

1.36 (1.13–1.64); p = 0.0008

1.51 (1.25–1.81); p < 0.0001

N° of metastatic sites

> 2 vs ≤ 2

1.54 (1.34–1.77); p < 0.0001

1.52 (1.30–1.77); p < 0.0001

ECOG PS

≥2 vs 0–1

2.86 (2.36–3.48); p < 0.0001

2.35 (1.92–2.88); p < 0.0001