Table 3 Cox proportional-hazards regression: univariate and multivariate analyses of Progression Free Survival

VARIABLE (Comparator)

HR (95% CI); p - value

HR (95% CI); p - value

BMI

≥ 25 vs < 25

0.46 (0.39–0.54); p < 0.0001

0.71 (0.56–0.90); p < 0.0001

Weight^a

0.97 (0.96–0.98); p < 0.0001

0.99 (0.98–1.01); p = 0.1580

irAEs of any grade

Yes vs No

0.48 (0.41–0.57); p < 0.0001

0.67 (0.54–0.83); p = 0.0002

 Melanoma

0.52 (0.42–0.66); p < 0.0001

0.67 (0.53–0.85); p = 0.0008

 Kidney

0.72 (0.58–0.91); p = 0.0062

0.67 (0.53–0.84); p = 0.0008

 Others

1.08 (0.65–1.78); p = 0.7556

0.69 (0.41–1.15); p = 0.1533

Sex

 Male vs

 Female

1.20 (1.01–1.42); p = 0.0314

1.03 (0.86–1.22); p = 0.7252

Age

 Elderly vs

 Non-elderly

0.96 (0.82–1.12); p = 0.6394

–

Treatment line

 Non-first vs First

1.62 (1.33–1.96); p < 0.0001

1.61 (1.32–1.93); p < 0.0001

N° of metastatic sites

 > 2 vs ≤ 2

1.46 (1.27–1.68); p < 0.0001

1.42 (1.21–1.67); p < 0.0001

ECOG PS

 ≥2 vs 0–1

2.60 (2.13–3.17); p < 0.0001

2.06 (1.67–2.52); p < 0.0001