Table 4 Cox proportional-hazards regression: univariate and multivariate analyses of Overall Survival

VARIABLE

(Comparator)

HR (95% CI); p – value

HR (95% CI); p - value

BMI

≥ 25 vs < 25

0.33 (0.28–0.41); p < 0.0001

0.49 (0.38–0.64); p < 0.0001

Weight^a

0.97 (0.96–0.97); p < 0.0001

0.99 (0.99–1.01); p = 0.1884

irAEs of any grade

Yes vs No

0.45 (0.37–0.54); p < 0.0001

0.82 (0.65–1.04); p = 0.1085

 Melanoma

0.49 (0.38–0.64); p < 0.0001

0.67 (0.51–0.87); p = 0.0036

 Kidney

0.56 (0.42–0.74); p = 0.0001

0.61 (0.45–0.80); p = 0.0005

 Others

1.11 (0.62–1.96); p = 0.7337

0.71 (0.40–1.28); p = 0.2632

Sex

 Male vs Female

1.50 (1.23–1.83); p < 0.0001

1.33 (1.09–1.63); p = 0.0044

Age

 Elderly vs Non-elderly

1.11 (0.93–1.32); p = 0.2401

–

Treatment line

 Non-first vs First

1.58 (1.26–1.97); p = 0.0001

1.42 (1.15–1.77); p = 0.0012

N° of metastatic sites

 > 2 vs ≤ 2

1.52 (1.29–1.78); p < 0.0001

1.41 (1.17–1.69); p = 0.0002

ECOG PS

 ≥2 vs 0–1

2.07 (1.87–2.29); p < 0.0001

2.59 (2.09–3.21); p < 0.0001