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Table 6 Cox proportional-hazards regression: univariate and multivariate analyses according to non-overweight (< 25), overweight (25-30) and obese (≥ 30) BMI levels

From: A multicenter study of body mass index in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors: when overweight becomes favorable

  Univariate Analysis Multivariate Analysis
VARIABLE
(Comparator)
HR (95% CI); p - value HR (95% CI); p - value
BMI
(< 25)
Time to Treatment Failure
25–30
≥ 30
0.49 (0.41–0.58); p < 0.0001
0.60 (0.47–0.77); p = 0.0001
0.67 (0.53–0.84); p = 0.0008
0.86 (0.61–1.24); p = 0.4414
BMI
(< 25)
Progression Free Survival
25–30
≥ 30
0.46 (0.39–0.55); p < 0.0001
0.46 (0.35–0.61); p < 0.0001
0.71 (0.56–0.89); p = 0.0044
0.80 (0.55–1.17); p = 0.2669
BMI
(< 25)
Overall Survival
25–30
≥ 30
0.33 (0.27–0.41); p < 0.0001
0.34 (0.25–0.48); p < 0.0001
0.49 (0.37–0.64); p < 0.0001
0.61 (0.39–0.94); p = 0.0258
  1. The used covariates (not shown) were: weight (continuous), irAEs of any grade, primary tumors, sex, line of treatment, ECOG-PS, number of metastatic sites