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Table 7 Cox proportional-hazards regression: univariate and multivariate analyses according to normal weight (18.5-25), overweight (25-30) and obese (≥ 30) BMI levels

From: A multicenter study of body mass index in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors: when overweight becomes favorable

 

Univariate Analysis

Multivariate Analysis

VARIABLE

(Comparator)

HR (95% CI); p - value

HR (95% CI); p - value

BMI

(18.5–25)

Time to Treatment Failure

25–30

≥ 30

0.51 (0.43–0.61); p < 0.0001

0.63 (0.49–0.81); p = 0.0003

0.65 (0.51–0.82); p = 0.0004

0.79 (0.55–1.15); p = 0.2300

BMI

(18.5–25)

Progression Free Survival

25–30

≥ 30

0.49 (0.41–0.58); p < 0.0001

0.48 (0.37–0.64); p < 0.0001

0.68 (0.53–0.87); p = 0.0016

0.72 (0.49–1.06); p = 0.0991

BMI

(18.5–25)

Overall Survival

25–30

≥ 30

0.35 (0.29–0.43); p < 0.0001

0.37 (0.27–0.51); p < 0.0001

0.46 (0.35–0.61); p < 0.0001

0.50 (0.32–0.79); p = 0.0029

  1. The used covariates (not shown) were: weight (continuous), irAEs of any grade, primary tumors, sex, line of treatment, ECOG-PS, number of metastatic sites
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