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Fig. 7 | Journal for ImmunoTherapy of Cancer

Fig. 7

From: Increased intratumoral mast cells foster immune suppression and gastric cancer progression through TNF-α-PD-L1 pathway

Fig. 7

A proposed model of cross-talks among mast cells, T cells, and tumor cells leading to mast cell-mediated immunosuppressive and protumorigenic effects in the GC microenvironment. CXCL12-CXCR4 chemotaxis mediates the recruitment and accumulation of mast cells into the GC microenvironment, which could be up-regulated PD-L1 expression via NF-κB signaling pathway activation by tumor-derived TNF-α. Mast cells inhibit T-cell proliferation and function in a PD-L1-dependent manner in GC, which promotes GC progression

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