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Fig. 5 | Journal for ImmunoTherapy of Cancer

Fig. 5

From: NKG2D signaling certifies effector CD8 T cells for memory formation

Fig. 5

Early responses to IL-15 was not affected by NKG2D blockade, while S6 phosphorylation was reduced. Effector pMel CD8 T cells were generated as described in Fig. 1a. Shown are the representative plots (a, c) of pSTAT5 staining and graphs (b, d) summarizing the percentage of pMel CD8 T cells (CD90.1+) expressing pSTAT5 after ex vivo exposure to IL-15 for 30 min. Splenocytes were isolated one day after injecting the anti-NKG2D blocking antibody (a, b) or one day after the in vivo killing assay (c, d). Unstimulated cells were used as control. Representative plots (e) and graphs (f) summarizing the percentage of pMel cells (CD90.1+) expressing pS6 ex vivo before and after the in vivo killing assay in the presence or absence of NKG2D blockade. g Splenocytes from (EF) were stimulated with IL-15 for 30 min. The percentage of pSTAT5+ pMel cells that express pS6 is summarized in the graph. Data shown are representative of two independent experiments

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