Fig. 7
From: NKG2D signaling certifies effector CD8 T cells for memory formation
Memory cells formed upon transient NKG2D blockade were not protective against melanoma B16 tumor. Memory pMel CD8 T cells were generated as in Fig. 1a. (a-b) B16 melanoma cells were injected during the memory phase (>d40 after the in vivo CTL assay and NKG2D blockade). Tumor growth (a) and incidence (b) were followed over time. Individual lines in graphs shown in A represent the tumor growth of a single mouse. Tumor incidence in mice with memory pMel CD8 T cells formed in absence (top graph) or presence (middle graph) of transient NKG2D blockade is indicated on each graph. Naïve C57BL/6 mice were used as control. Proportion of tumor take are also represented. The graph shows the results of one of two independent experiments