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Table 1 Laboratory data

From: Acute liver injury in the context of immune checkpoint inhibitor-related colitis treated with infliximab

Variable

Reference Range, Adultsa

Result

White blood cell count (per μL)

4000–11,000

5200

Hemoglobin (g/dL)

14.0–18.0

13.0

Mean corpuscular volume (fL)

82–98

87

Platelet count (per μL)

140,000–440,000

208,000

Sodium (mEq/L)

136–145

143

Blood urea nitrogen (mg/dL)

8–20

16

Creatinine (mg/dL)

0.70–1.30

1.19

Lactate dehydrogenase (U/L)

313–618

870

Hepatitis A IgM antibody

Negative

Negative

Hepatitis B surface antigen

Non-reactive

Non-reactive

Hepatitis B surface antibody (mIU/mL)

< 5.0 (Negative)

< 5.0 (Negative)

Hepatitis B total core antibody

Non-reactive

Non-reactive

Hepatitis B DNA (IU/mL)

Undetected

Undetected

Hepatitis C antibody

Non-reactive

Non-reactive

Hepatitis E IgM antibody

Negative

Negative

Hepatitis E IgG antibody

Negative

Positive

CMV IgM (units)

0.0–0.9

0.9 (Equivocal)

CMV IgG (units)

0.00–0.79

11.90

EBV viral capsid antigen IgM antibody

Negative

Negative

EBV viral capsid antigen IgG antibody

Negative

Positive

EBV nuclear antigen IgG antibody

Negative

Positive

HSV-1 DNA (copies/mL)

Not detected

Not detected

HSV-2 DNA (copies/mL)

Not detected

Not detected

Anti-nuclear antibody titer

< 1:40

< 1:40

Anti-smooth muscle antibody

Negative

Negative

Anti-mitochondrial antibody

Negative

Negative

Anti-liver kidney microsomal type 1 antibody

Negative

Negative

Ceruloplasmin (mg/dL)

19.0–31.0

30.5

Ferritin (ng/mL)

30–400

638

Iron (μg/dL)

49–181

51

Total iron binding capacity (μg/dL)

250.0–450.0

247.7

HFE gene mutation analysis

One copy of H63D detected

Triglycerides (mg/dL)

< 150

166b

LDL-cholesterol (mg/dL)

< 100

74b

Anti-tissue transglutaminase IgA antibody (U/mL)

< 4.0

< 1.2

Anti-tissue transglutaminase IgG antibody (U/mL)

< 6.0

< 1.2

  1. aReference values are affected by variables including patient population and laboratory methods employed
  2. bThese results were obtained over 1 year prior to presentation