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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Exceptional response and multisystem autoimmune-like toxicities associated with the same T cell clone in a patient with uveal melanoma treated with immune checkpoint inhibitors

Fig. 2

a and b Multiplexed immunofluorescence of hepatic metastasis. Staining of nuclei (Hoechst) MITF, PD-L1, CD8a and CD11b is shown at 20X magnification. Letters indicate respective color representation in the images, including blue (B), green (G), white (W), red (R) and magenta (M). Different staining combinations are shown and indicated at the top of each image. MITF expression identifies cancer cells. From top left to bottom right, the images show significant infiltration with CD8a and CD11b expressing immune cells and elimination of tumor cells in the areas of immune infiltrates. PD-L1 expression is almost exclusively limited to myeloid infiltrating immune cells (CD11 + PD-L1+). The primary tumor was imaged using the same strategy (see Additional file 1: Supplemental method)

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