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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: Exceptional response and multisystem autoimmune-like toxicities associated with the same T cell clone in a patient with uveal melanoma treated with immune checkpoint inhibitors

Fig. 3

Expansion of clonal T-cells from Primary Uveal Melanoma. Panel a depicts TCR clonality metrics in the TME relative to published result regarding the association of these metrics with recently reported responses to anti-PD1 therapy in cutaneous melanoma [15]. Panel b depicts amino acid sequence of corresponding uniquely rearranged variable TCR β-chain regions in primary eye tumor, hepatic metastasis, PBMCs, and inflamed duodenum. TCR sequence, “CASRVTSGGYNEQFF” was expanded from the primary eye tumor (4thmost prevalent) to become the most abundant clone in hepatic metastasis, and peripheral blood that persisted more than 6 months after treatment initiation. The same clone is seen as the top infiltrating T-cell clone in duodenal crypt inflammation

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