Fig. 4

Clinical, genomic and immune correlates in INSPIRE. A composite display of 107 clinical, genomic, and immune correlates for each patient (per column) at baseline and on-treatment tumor and peripheral blood samples, sorted in order of decreasing percentage change in tumor measurement from baseline. Cohort and best RECIST 1.1 response for each patient is shown in the color track below the bar plot. Data for each row is z-score normalized. C index for variable is shown (right), with statistically significant associations highlighted in blue or red (respectively, negative and positive associations with favorable clinical response). PGA, percent genome altered