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Fig. 6 | Journal for ImmunoTherapy of Cancer

Fig. 6

From: Immune-enrichment of non-small cell lung cancer baseline biopsies for multiplex profiling define prognostic immune checkpoint combinations for patient stratification

Fig. 6

RNA and protein conserved ICP coexpression groups ranked for NSCLC patient stratification. a-c Graphs depicting R package generated correlation studies made between all ICPs from RNA and TMA datasets to reveal ICP coexpression dynamics stratifying patients. From left to right, RNA expression of ICPs from the TCGA LUAD (n = 504) and LUSC (n = 494) patient samples (left two graph columns), were compared to that of ICP and CD3-ICP expression from all TMA dataset patient (n = 73) samples (right two graph columns). a Correlograms demonstrating ICP coexpression clustering, where black boxes demarcate most highly correlating ICP. b PCA for visualization of multi-dimensional ICP coexpression, relative to distributions patient data (blue circles), where yellow shaded PC quadrants are occupied by ICP coexpressing groups having positive associations with OS, defined by Additional file 1: Figure S7. c Mean correlations of ICP coexpression demonstrate those most abundantly expressed relative to all other ICPs in NSCLC patients. Analyses were performed using alternative software (see Online Methods) by two independent operators. PC1, principal component 1; PC2, principal component 2

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