Fig. 6
From: Antisense oligonucleotide targeting CD39 improves anti-tumor T cell immunity
Therapeutic efficacy of CD39 ASO in combination with anti-PD-1 antibody. (a) Mice were injected intramammary with 250,000 EMT6 murine breast cancer cells. Once tumors reached 50–80 mm3 (Day 8) mice were injected with CD39 ASO, control oligo 1 and/or anti-PD-1 mAb (all i.p.) on indicated days. Mice were treated with CD39 ASO on five days in the first week and on two days in the second week. Tumor growth is depicted as spider plots (b) and as bar graph indicating cumulative tumor volume on day 25 post cell injection (c). Also included in (c) are euthanized mice reaching termination criteria (tumor volume above 1200 mm3) before day 25. In all cases each data point represents a mouse. Pooled data from two independent repeats. Error bars indicate SD. Asterisks indicate significant differences compared to control oligo 1 group