Table 1 Different published studies exploring the impact of the global lymphopenia or NK and T cell subsets on relapse-free survival (RFS) or overall survival (OS) in patients with solid tumors

Sarcoma

193

Overall Lymphopenia

<1000 (24%)

1.46

1.0-2.1

0.05

[68]

Ewing Sarcoma

24

Overall Lymphopenia

<500 (33%)

4.34

1.35-14.28

0.007

[75]

Renal Cell Carcinoma

424

Overall Lymphopenia

≤1300 (28.06%)

1.75

1.14-2.67

0.0102

[65]

Colon Carcinoma

260

Overall Lymphopenia

<1000 (19%)

1.56

1.0-2.43

0.048

2.35

2.34-4.14

0.003

[66]

Breast Carcinoma

195

Overall Lymphopenia

<1000 (28.7%)

1.82

1.27-2.59

0.001

2.23

1.36-3.65

0.001

[89]

Non Hodgkin Lymphoma

322

Overall Lymphopenia

<1000 (25%)

1.71

1.2-2.4

0.002

1.48

1.03-2.21

0.04

[68]

Diffuse large B cell lymphoma (DLBCL)

151

Overall Lymphopenia

≤1000 (35.8%)

2.38

1.29-4.34

0.005

[90]

DLBCL

221

Overall Lymphopenia

<1000 (38.9%)

2.72

1.61-4.60

<0.001

2.51

1.38-4.58

0.003

[80]

DLBCL

89

Overall Lymphopenia

<840 (23%)

3.81

1.72-8.42

0.0009

4.38

1.88-13.28

0.0012

[79]

Follicular Lymphoma

228

Overall Lymphopenia

≤1000 (28%)

1.72

1.33-2.24

<10^-4

[70]

Hodgkin Lymphoma

476

Overall Lymphopenia

<600 (18.06%)

1.59

0.96-2.58

0.06

1.25

0.74-2.15

0.4

[82]

Hodgkin Lymphoma

2497

Overall Lymphopenia

<600 (11%)

1.38

0.002

[81]

Multiple Myeloma

537

Overall Lymphopenia

<1400 (62%)

1.71

1.53-2.35

<10^-4

[92]

ATLL

60

Overall Lymphopenia

<1000 (35.6%)

1.93

0.004

2.37

0.0003

[93]

PTCLU

69

Overall Lymphopenia

<1000 (38%)

4.0

1.9-8.3

<10^-4

[71]

PTCL-NOS

118

Overall Lymphopenia

1000 (30.5%)

1.94

1.19-3.18

0.008

2.24

1.33-3.78

0.002

[72]

Breast Carcinoma

287

Overall Lymphopenia

<1000 (27%)

1.48

1.1-2.0

0.01

1.8

1.3-2.4

0.0002

[68]

Breast Carcinoma

195

Overall Lymphopenia

<1000 (28.7%)

1.82

1.27-2.59

0.001

2.23

1.36-3.65

0.001

[89]

Breast Carcinoma 1st relapse

128

Overall Lymphopenia

<1000 (44.27%)

1.8

1.15-2.82

0.01

[50]^b

Breast Carcinoma 1st relapse

1^st relapse

103

Overall Lymphopenia

<700 (22.3%)

2.03

1.17-3.50

0.016

[21]^b

Breast Carcinoma 1st relapse

1^st relapse

103

CD4⁺ Lymphopenia

≤450 (53.4%)

2.50

1.57-3.98

<10^-4

[21]^b

Breast Carcinoma >2^nd relapse

101

CD4⁺ Lymphopenia

≤450 (70.3%)

1.35

0.87-1.1

0.183

1.69

1.04-2.78

0.036

[21]

Metastatic Solid Tumors

219

CD4⁺ Lymphopenia

≤450 (47.9%)

1.5

1.1-2.1

0.017

[20]

Metastatic Solid Tumors

213

CD4⁺ Lymphopenia

<450 (49.7%)

7.7^a

1.6-35^a

0.007^a

[19]^a

Non Hodgkin Lymphoma

88

CD8⁺ Lymphopenia

<200

3.30

1.21-9.0

0.01

[88]

Follicular Lymphoma

75

NK cells Lymphopenia

<150 (44%)

6.73

0.76-59

0.08

[69]

DLBCL

136

NK cells Lymphopenia

≤80 (37.5%)

1.81

1.27-2.57

0.001

[94]