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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: Interleukin-1 alpha increases anti-tumor efficacy of cetuximab in head and neck squamous cell carcinoma

Fig. 3

IL-1α overexpression enhances the anti-tumor efficacy of cetuximab. Female athymic nu/nu mice bearing IL-1α overexpressing (#20) or control (#16) SQ20B tumors were treated with cetuximab (CTX, 2 mg/kg, twice/week) or IgG for 3 weeks. Overexpression was confirmed by ELISA (inset). Tumors were measured three times weekly. Tumor growth curves shown were stopped after a mouse in any treatment group reached euthanasia criteria. Error bars = SEM. N = 4–5 mice/treatment group. *: p < 0.05

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