Fig. 2
From: Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy
Combination of N-803 and αPD-L1 decreases 4T1 lung metastasis and improves survival. a-c Mice were implanted with 4T1 tumors as in Fig. 1 and treated on days 8 and 14 with 1 μg N-803 (s.c.) and/or 200 μg αPD-L1 (i.p.) on days 8, 11, and 14. Graphs of tumor volumes of individual animals at day 25 post-tumor implant in (a) and number of lung metastases in individual mice 26 days after tumor implant (b) show mean ± SD. c Table denotes the distribution of number of lung metastases and % reduction in mean versus PBS. Data are representative of 2 independent experiments, n = 20–23 mice. d-g Mice were implanted with 4T1 tumors as in Fig. 1 and treated at days 9 and 13 with N-803 and/or αPD-L1 on days 9, 11, and 13. The primary tumor was surgically resected at day 15. Graphs of tumor volumes of individual animals at day 14 post-tumor implant (d) and number of lung metastases in individual mice at day 28 (e) show mean ± SD. f Table denotes the distribution of number of lung metastases per mouse and % reduction in mean versus PBS. Data are representative of 2 independent experiments, n = 15–19 mice. g Survival curves (inset: mOS) show % survival. Data are representative of 2 independent experiments, n = 13–19 mice