Fig. 3
From: Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy
CD8+ T cells and NK cells contribute to the anti-tumor efficacy of N-803 + αPD-L1 combination. Mice were implanted with 4T1 tumors as in Fig. 1 and treated on days 13 and 17 with N-803 and αPD-L1 on days 13, 15, and 17. CD8-expressing cells and NK cells were depleted on days 10, 11, 12, 16, and 19 using 100 μg anti-CD8 and/or 25 μl anti-asialo-GM1 (i.p.). Graphs show tumor volumes of individual mice (a) or number of lung metastases in individual mice at day 23 post-tumor implant (b) as mean ± SD. c Table denotes the distribution of the number of lung metastases per mouse and % reduction in mean versus PBS. Data combined from 2 independent experiments, n = 23–25 mice/group total