Characteristics | Training cohort (n = 153) | Validation cohort (n = 65) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Patients | HHLA2 expression | Patients | HHLA2 expression | |||||||
NO. | % | Low | High | P-value | NO. | % | Low | High | P-value | |
All patients | 153 | 100.0 | 78 | 75 | Â | 65 | 100.0 | 21 | 44 | Â |
Age | Â | Â | Â | Â | 0.805 | Â | Â | Â | Â | 0.601 |
  ≤ 60 | 78 | 51.0 | 39 | 39 |  | 31 | 47.7 | 11 | 20 |  |
  >  60 | 75 | 49.0 | 39 | 36 |  | 34 | 52.3 | 10 | 24 |  |
Liver cirrhosis | Â | Â | Â | Â | 0.199 | Â | Â | Â | Â | 0.486 |
 Absent | 131 | 85.6 | 64 | 67 |  | 56 | 86.2 | 19 | 37 |  |
 Present | 22 | 14.4 | 14 | 8 |  | 9 | 13.8 | 2 | 7 |  |
ALBI grade | Â | Â | Â | Â | 0.468 | Â | Â | Â | Â | 0.194 |
 1 | 122 | 79.7 | 64 | 58 |  | 39 | 60.0 | 15 | 24 |  |
 2 | 31 | 20.3 | 14 | 17 |  | 26 | 40.0 | 6 | 20 |  |
Tumor size | Â | Â | Â | Â | 0.594 | Â | Â | Â | Â | 0.575 |
  ≤ 5 cm | 64 | 41.8 | 31 | 33 |  | 37 | 56.9 | 13 | 24 |  |
  >  5 cm | 89 | 58.2 | 47 | 42 |  | 28 | 43.1 | 8 | 20 |  |
Tumor differentiation | Â | Â | Â | Â | 0.833 | Â | Â | Â | Â | 0.368 |
 I - II | 126 | 82.4 | 65 | 61 |  | 30 | 46.2 | 8 | 22 |  |
 III - IV | 27 | 17.6 | 13 | 14 |  | 35 | 53.8 | 13 | 22 |  |
Tumor number | Â | Â | Â | Â | 0.885 | Â | Â | Â | Â | 0.894 |
 Single | 113 | 73.9 | 58 | 55 |  | 52 | 80.0 | 17 | 35 |  |
 Multiple | 40 | 26.1 | 20 | 20 |  | 13 | 20.0 | 4 | 9 |  |
MVI | Â | Â | Â | Â | 0.066 | Â | Â | Â | Â | 0.119 |
 Absent | 116 | 75.8 | 64 | 52 |  | 53 | 81.5 | 19 | 34 |  |
 Present | 37 | 24.2 | 14 | 23 |  | 12 | 18.5 | 2 | 10 |  |
LN metastasis | Â | Â | Â | Â | 0.071 | Â | Â | Â | Â | 0.013 |
 Absent | 134 | 87.6 | 72 | 62 |  | 35 | 53.8 | 16 | 19 |  |
 Present | 19 | 12.4 | 6 | 13 |  | 30 | 46.2 | 5 | 25 |  |
CA19–9a |  |  |  |  | < 0.001 |  |  |  |  | 0.078 |
  ≤ 37 U/L | 69 | 46.3 | 46 | 23 |  | 30 | 46.2 | 13 | 17 |  |
  >  37 U/L | 80 | 53.7 | 30 | 50 |  | 35 | 53.8 | 8 | 27 |  |
CEAa |  |  |  |  | < 0.001 |  |  |  |  | 0.001 |
  ≤ 5 ng/ml | 121 | 81.2 | 72 | 49 |  | 36 | 55.4 | 18 | 18 |  |
  >  5 ng/ml | 28 | 18.8 | 4 | 24 |  | 29 | 44.6 | 3 | 26 |  |
AJCC 8th | Â | Â | Â | Â | 0.053 | Â | Â | Â | Â | 0.024 |
 I-II | 122 | 79.7 | 67 | 55 |  | 19 | 29.2 | 10 | 9 |  |
 IIIa-IIIb | 31 | 20.3 | 11 | 20 |  | 46 | 70.8 | 11 | 35 |  |