Fig. 6

Cytopathology analysis of bone marrow and histopathology analysis of mouse vital organs (spleen, liver, intestine). (a) Representative picture of May-Grünwald Giemsa staining for bone marrow cytospin from both treatment groups (TEG001 and TEG-LM1 mock) with pleomorphic population of cells with all maturation stages including numerous blasts (B), promyelocytes (Pr), dysplastic immature cells (DiC), megakaryocytes (Mk) and a mixed population of myeloid and erythroid (E) lineages; (b) Representative pictures for H&E staining of mouse spleen for both treatment group (TEG001 and TEG-LM1 mock) with non-neoplastic, lympho/histiocytic hyperplastic lesion with mitotic figure (arrows), apoptotic bodies (arrowhead) and erythroid precursors (*). Magnification: 40X; (c) Representative pictures for H&E staining of mouse liver for both treatment group (TEG001 and TEG-LM1 mock) with small focus of extramedullary hematopoiesis (arrows) in all samples, which could be due to the mouse model with engraftment of human CD34⁺ progenitor cells. Magnification: 20X; (d) Representative pictures for H&E staining of mouse intestine for TEG001-treated group (left) showing multifocal lymphocytic infiltration of lymphoid cells (arrows) in a small tract of the small intestine (background lesion) and TEG-LM1 mock-treated group (right) with normal jejunum. Magnification: 10X. Shown are representative pictures from an individual mouse of both TEG001 and TEG-LM1 mock group (n = 3 mice/group) with no significant differences in overall cytopathology and histology features between treatment groups