Fig. 1

Genetic ablation of Dll1 in CD11c⁺ cells in mice accelerates tumor growth with decreased survival. a Deletion of Notch ligand genes Dll1 and Jag2 in CD11c⁺ cells was confirmed by RT-PCR performed with RNA isolated from CD11c⁺ or CD11c⁻ cells from splenocytes of genetically modified and wild-type mice. Lewis lung carcinoma (LLC) tumor growth (b) and log-rank survival curves (c) for mice with hetero or homozygous deletion of Dll1 in CD11c⁺ cells and wild-type littermates. d Pancreatic MT5 tumor growth in CD11c⁺ cell-specific Dll1^−/− and wild-type mice. e LLC tumor growth in CD11c⁺ cell-specific Jag2^−/− and wild-type littermates. Mean ± SEM, 8–10 mice per group; *, p < 0.05; **, p < 0.01