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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T cell immunity

Fig. 2

CD11c-lineage-specific ablation of Notch ligands alters cytokine production. IFN-γ and IL-4-producing cells were enumerated by ELISPOT assay among LLC tumor-infiltrating lymphocytes (TIL) from mice with CD11c lineage-specific deletion of Dll1 and wild-type littermates following re-stimulation with anti-CD3/CD28 beads (a, b) or with LLC tumor antigenic peptide MUT1 (FEQNTAQP) loaded on autologous splenocytes for 48 h (c). d Evaluation of IFN-γ-producing cells in a pool of tumor-draining lymph node cells from the same mice following re-stimulation with anti-CD3/CD28 beads. e Evaluation of IFN-γ and IL-4-producing cells among tumor-infiltrating lymphocytes from Jag2−/− or wild-type littermate mice following re-stimulation with anti-CD3/CD28 beads. Mean ± SEM, 5 mice per group; *, p < 0.05, **, p < 0.01

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