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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: STING agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models

Fig. 1

Increased survival and immune activation in mice treated with gemcitabine and STING agonist. a Experimental treatment strategy of subcutaneous (s.c.) pancreatic tumors in C57BL/6 mice. Control not treated (NT) and experimental mice were treated as indicated. b Kaplan-Meier survival curves are shown for the indicated control and experimental groups. Data are representative of 3 independent experiments (n = 14–15 mice per group). c Tumors were collected 19 or 20 days after implantation and tumor weight measured. d, e Tumors were processed into single cell suspensions and CD4:CD8 ratios and percent Foxp3+ cells within the CD8+ T cell compartment determined by flow cytometry. f Splenic CD8+ T cells were isolated by immunomagnetic sorting and tested in IFN-γ ELISPOT assays using KPC1242 tumor cells as stimulators. Values are mean IFN-γ spot forming unit (SFU) ± SD, n = 3 independent experiments. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001

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