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Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: STING agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models

Fig. 4

DMXAA induces the production of proinflammatory cytokines and chemokines in vivo. a Timeline for intra-tumoral treatment with DMXAA. Control mice were not treated (NT). b Representative histopathologic tissue specimens stained with Masson’s trichrome from untreated and DMXAA-treated mice. Tumor tissues (T) stain red while collagen stains blue. c, d Multiplex analysis of intra-tumoral cytokines and chemokines in non-treated (NT, blue bars) or DMXAA-treated (red bars) tumors. Values are mean ± SD, n = 9 control non-treated and 15 DMXAA treated mice from 2 independent experiments

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