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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids

Fig. 2

a: Diagram of the PDO and allogeneic CD8 T cell co-culture model. b: Example showing GFP fluorescence imaging of a co-culture model treated with the bispecific untargeted control antibody and cibisatamab over a period of 8 days. c: Growth curves generated with different effector to target (E:T) ratios in the CEAhi PDO CRC-01 during assay development

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