Table 2 Clinical characteristics stratified by the resistance to steroid
Covariate | Failed steroid tapering after SIT N = 28 | Successful steroid tapering after SIT N = 50 | P |
|---|---|---|---|
Diarrhea grade, No. (%) | 0.087 | ||
1–2 | 1 (4) | 11 (22) | |
3 | 21 (75) | 32 (64) | |
4 | 6 (21) | 7 (14) | |
Colitis grade, No. (%) | 0.016 | ||
1–2 | 9 (32) | 33 (66) | |
3 | 17 (61) | 15 (30) | |
4 | 2 (7) | 2 (4) | |
Symptom onset, No. (%) | 0.478 | ||
Abrupt | 11 (39) | 25 (50) | |
Gradual | 17 (61) | 25 (50) | |
Positive lactoferrin at time of onset, No. (%) | 22 (79) | 26 (52) | 0.028 |
Overall duration of steroids, mean days (SD) | 99 (46) | 58 (39) | < 0.001 |
Duration of hospitalization, mean days (SD) | 15 (9) | 9 (6) | 0.001 |
Duration of symptoms, mean days (SD) | 72 (42) | 19 (19) | < 0.001 |
Endoscopic features, No. (%) | 0.015 | ||
Ulcer | 15 (60) | 12 (35) | |
Non-ulcerative inflammation | 4 (16) | 18 (53) | |
Normal | 6 (24) | 4 (12) | |
Duration from onset to SIT, mean days (SD) | 28 (32) | 12 (11) | 0.002 |
Calprotectin at time of onset, mean (SD) | 363 (329) | 311 (272) | 0.610 |
Rapid improvement with steroid before SIT, No. (%) | 8 (29) | 31 (62) | 0.009 |
Failed steroid tapering before SIT, No. (%)a | 23 (82) | 22 (44) | 0.002 |
Multiple hospitalizations, No. (%) | 21 (75) | 13 (26) | < 0.001 |
Recurrent IMC, No. (%) | 10 (36) | 6 (12) | 0.019 |