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Table 2 Clinical characteristics stratified by the resistance to steroid

From: Early introduction of selective immunosuppressive therapy associated with favorable clinical outcomes in patients with immune checkpoint inhibitor–induced colitis

Covariate Failed steroid tapering after SIT N = 28 Successful steroid tapering after SIT N = 50 P
Diarrhea grade, No. (%)    0.087
1–2 1 (4) 11 (22)  
3 21 (75) 32 (64)  
4 6 (21) 7 (14)  
Colitis grade, No. (%)    0.016
1–2 9 (32) 33 (66)  
3 17 (61) 15 (30)  
4 2 (7) 2 (4)  
Symptom onset, No. (%)    0.478
Abrupt 11 (39) 25 (50)  
Gradual 17 (61) 25 (50)  
Positive lactoferrin at time of onset, No. (%) 22 (79) 26 (52) 0.028
Overall duration of steroids, mean days (SD) 99 (46) 58 (39) < 0.001
Duration of hospitalization, mean days (SD) 15 (9) 9 (6) 0.001
Duration of symptoms, mean days (SD) 72 (42) 19 (19) < 0.001
Endoscopic features, No. (%)    0.015
Ulcer 15 (60) 12 (35)  
Non-ulcerative inflammation 4 (16) 18 (53)  
Normal 6 (24) 4 (12)  
Duration from onset to SIT, mean days (SD) 28 (32) 12 (11) 0.002
Calprotectin at time of onset, mean (SD) 363 (329) 311 (272) 0.610
Rapid improvement with steroid before SIT, No. (%) 8 (29) 31 (62) 0.009
Failed steroid tapering before SIT, No. (%)a 23 (82) 22 (44) 0.002
Multiple hospitalizations, No. (%) 21 (75) 13 (26) < 0.001
Recurrent IMC, No. (%) 10 (36) 6 (12) 0.019
  1. aAvailable for the 79 patients that received steroids
  2. Abbreviation: SIT, selective immunosuppressive therapy