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Table 4 Response to steroid treatment before SIT and outcomes

From: Early introduction of selective immunosuppressive therapy associated with favorable clinical outcomes in patients with immune checkpoint inhibitor–induced colitis

Covariate Improvement with steroid before SIT N = 38 No improvement with steroid before SIT N = 41 P
Multiple hospitalization, No. (%) 12 (38) 23 (64) 0.051
Failed steroid tapering after SIT, No. (%) 8 (21) 20 (50) 0.010
Overall duration of steroids, mean days (SD) 63 (40) 113 (45) < 0.001
Duration of hospitalization, mean days (SD) 9 (6) 17 (11) 0.001
Duration of symptoms, mean days (SD) 25 (26) 83 (42) < 0.001
Number of steroids tapering attempts, No. (%)    0.014
1 24 (63) 11 (28)  
2–4 14 (37) 29 (73)  
Endoscopic remission, No. (%) 10 (67) 13 (65) 1.000
Histologic remission, No. (%)a 11 (73) 13 (52) 0.318
Recurrent IMC, No. (%) 5 (13) 11 (27) 0.166
  1. aAvailable for 40 patients
  2. Abbreviation: SIT, selective immunosuppressive therapy
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