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Table 4 Response to steroid treatment before SIT and outcomes

From: Early introduction of selective immunosuppressive therapy associated with favorable clinical outcomes in patients with immune checkpoint inhibitor–induced colitis

Covariate

Improvement with steroid before SIT N = 38

No improvement with steroid before SIT N = 41

P

Multiple hospitalization, No. (%)

12 (38)

23 (64)

0.051

Failed steroid tapering after SIT, No. (%)

8 (21)

20 (50)

0.010

Overall duration of steroids, mean days (SD)

63 (40)

113 (45)

< 0.001

Duration of hospitalization, mean days (SD)

9 (6)

17 (11)

0.001

Duration of symptoms, mean days (SD)

25 (26)

83 (42)

< 0.001

Number of steroids tapering attempts, No. (%)

  

0.014

1

24 (63)

11 (28)

 

2–4

14 (37)

29 (73)

 

Endoscopic remission, No. (%)

10 (67)

13 (65)

1.000

Histologic remission, No. (%)a

11 (73)

13 (52)

0.318

Recurrent IMC, No. (%)

5 (13)

11 (27)

0.166

  1. aAvailable for 40 patients
  2. Abbreviation: SIT, selective immunosuppressive therapy