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Table 5 Effect of timing of SIT initiation after IMC onset on outcomes among patients who had different response to steroid therapy

From: Early introduction of selective immunosuppressive therapy associated with favorable clinical outcomes in patients with immune checkpoint inhibitor–induced colitis

Covariate Poor response to steroid Good response to steroid
≤ 10 days N = 17 > 10 days N = 24 P ≤ 10 days N = 23 > 10 days N = 15 P
Multiple hospitalization, No. (%) 7 (41) 16 (84) 0.014 6 (32) 6 (46) 0.473
Failed steroid tapering after SIT, No. (%) 8 (50) 12 (50) 1.000 1 (4) 7 (47) 0.003
Recurrent IMC, No. (%) 4 (24) 7 (29) 0.736 4 (17) 1 (7) 0.630
Number of steroids tapering attempts, No. (%)    0.532    < 0.001
1 6 (38) 5 (21)   20 (87) 4 (27)  
2–4 10 (62) 19 (79)   3 (13) 11 (73)  
Overall duration of steroids, mean days (SD) 73 (43) 96 (57) 0.184 58 (34) 59 (30) 0.942
Duration of hospitalization, mean days (SD) 12 (9) 13 (8) 0.545 9 (6) 10 (8) 0.571
Duration of symptoms, mean days (SD) 39 (38) 57 (45) 0.179 17 (24) 39 (30) 0.016
  1. Abbreviation: SIT, selective immunosuppressive therapy