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Table 5 Effect of timing of SIT initiation after IMC onset on outcomes among patients who had different response to steroid therapy

From: Early introduction of selective immunosuppressive therapy associated with favorable clinical outcomes in patients with immune checkpoint inhibitor–induced colitis

Covariate

Poor response to steroid

Good response to steroid

≤ 10 days N = 17

> 10 days N = 24

P

≤ 10 days N = 23

> 10 days N = 15

P

Multiple hospitalization, No. (%)

7 (41)

16 (84)

0.014

6 (32)

6 (46)

0.473

Failed steroid tapering after SIT, No. (%)

8 (50)

12 (50)

1.000

1 (4)

7 (47)

0.003

Recurrent IMC, No. (%)

4 (24)

7 (29)

0.736

4 (17)

1 (7)

0.630

Number of steroids tapering attempts, No. (%)

  

0.532

  

< 0.001

1

6 (38)

5 (21)

 

20 (87)

4 (27)

 

2–4

10 (62)

19 (79)

 

3 (13)

11 (73)

 

Overall duration of steroids, mean days (SD)

73 (43)

96 (57)

0.184

58 (34)

59 (30)

0.942

Duration of hospitalization, mean days (SD)

12 (9)

13 (8)

0.545

9 (6)

10 (8)

0.571

Duration of symptoms, mean days (SD)

39 (38)

57 (45)

0.179

17 (24)

39 (30)

0.016

  1. Abbreviation: SIT, selective immunosuppressive therapy