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Table 1 Clinical trials with natural DC vaccination

From: The clinical application of cancer immunotherapy based on naturally circulating dendritic cells

  1. aStage IV melanoma patients or irresectable stage III melanoma patients
  2. bAnticipated capture of tumor antigens and maturation in vivo
  3. cmDC vaccination in combination with T-VEC intratumorally or anti-CTLA4 and anti-PDL1 intratumorally and anti-PD1 intravenously
  4. dAll mDCs obtained from the leukapheresis are injected
  5. Abbreviations: FSME, Frühsommer-meningoencephalitis; GM-CSF, granulocyte-macrophage colony-stimulating factor; mDC, myeloid dendritic cell; pDC, plasmacytoid dendritic cell; T-VEC, Talimogene laherparepvec. (source: and