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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: The correlations of tumor mutational burden among single-region tissue, multi-region tissues and blood in non-small cell lung cancer

Fig. 3

Impact of ITH on TMB assessment. a tTMB fold-change comparison between ITHi-high and ITHi-low patients. tTMB fold-change is computed by the mean tTMB of three-regions through a random iterated algorithm, then divided by that of the single region. b The conversion rate of tTMB level status between ITHi-high and ITHi-low patients if taking multi-region tTMB analysis. ITH index (ITHi) was calculated with specific formula displayed in Additional file 2: Supplementary Methods. ITHi ranges from 0 (lowest ITH) to 1 (highest ITH). If the tumor has less shared somatic genetic alterations after multi-region sequencing, the ITHi of this tumor will be higher. Otherwise, the ITHi of this tumor will be lower. Abbreviations: ITH, intratumor heterogeneity; TMB, tumor mutational burden; tTMB, tissue TMB

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