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Table 1 Laboratory test results on admission

From: Severe cytokine release syndrome resulting in purpura fulminans despite successful response to nivolumab therapy in a patient with pleomorphic carcinoma of the lung: a case report

Test   Result Reference Renge (Unit)
Complete blood count Neutrophils 2630 3500–9700 (/μL)
Lymphocytes 12.0 18.0–50.0 (%)
Monocytes 0.0 1.0–8.0 (%)
Eosinophils 0.0 0.0–7.0 (%)
Basophils 0.0 0.0–2.0 (%)
RBCs 492 376–516 × 10^4 (/μL)
Hemoglobin 12.8 11.2–15.2 (g/dL)
Hematocrit 39.0 34.3–45.2 (%)
RBCs MCV 79 80–101 (fL)
RBCs MCH 26.0 26.4–34.3 (pg)
RBCs MCHC 32.6 31.3–36.1 (%)
Platelets 1.1 14.0–37.9 × 10^4 (/μL)
Coagulation PT 23.3 10.0–13.0 (sec)
INR 1.94 0.90–1.13
Fibrinogen 185 170–410 (mg/dL)
D-dimer > 60 < 1 (μg/mL)
TAT > 120 < 4.0 (ng/mL)
Lupus anticoagulant 1.3 < 1.3 (normalized ratio)
vWF activity > 200 50–150 (%)
Thrombomodulin > 32 1.8–3.9 (FU/ml)
Blood Chemistry Urea 8.9 2.7–7.0 (mg/dL)
Creatinine 1.81 0.46–0.82 (mg/dL)
Sodium 137 135–145 (mEq/L)
Potassium 4.2 3.5–5.0 (mEq/L)
Chloride 101 98–108 (mEq/L)
Total protein 5.6 6.5–8.2 (g/dL)
Albumin 2.8 3.7–5.5 (g/dL)
Triglyceride 357 50–149 (mg/dL)
Alkaline phosphatase 878 104–338 (U/L)
Total bilirubin 4.0 0.3–1.2 (mg/dL)
Direct bilirubin 3 < 0.4 (mg/dL)
AST 1556 10–40 (U/L)
ALT 543 5–45 (U/L)
LDH 3679 120–245 (U/L)
CK 8040 5–210 (U/L)
CK-MB 184.2 < 5.0 (ng/mL)
Ferritin 3877 21.8–274.7 (ng/mL)
CRP 41.79 < 0.30 (mg/dL)
Cytokine or bioactive substance IL-1β 34.9 < 0.928 (pg/mL)
IL-2 < 15.6 < 15.6 (pg/mL)
soluble IL-2R 3630 145–519 (U/mL)
IL-6 1510 < 2.41 (pg/mL)
IL-10 20.0 < 2.03 (pg/mL)
IL-12 < 0.78 < 3.15 (pg/mL)
TNFα 251 < 1.79 (pg/mL)
INFγ 9260 < 20.6 (pg/mL)
G-CSF 753 10.5–57.5 (pg/mL)
ADAMTS-13 activity 37.8 70.0–120.0 (%)
ADAMTS-13 inhibitor < 0.5 < 0.5 (BU/mL)
  1. Abbreviations: MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, PT prothrombin time, INR international normalized ratio, TAT turnaround time, AST aspartate aminotransferase, ALT alanine aminotransferase, LDH lactate dehydrogenase, CK creatine kinase, CK-MB creatine kinase-muscle/brain, CRP C-reactive protein