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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Pneumonitis resulting from radiation and immune checkpoint blockade illustrates characteristic clinical, radiologic and circulating biomarker features

Fig. 2

a, b. CT scan of the chest demonstrated peripheral curvilinear consolidative opacities predominantly in the right upper lobe (black arrows, a, b), accompanied by more central areas of ground glass opacities (GGO) and traction bronchiectasis. Most of the findings are within the radiation field, however, a focal area of GGO extended posteriorly into the superior segment of the right lower lobe (white arrow, a) which is outside of the radiation field. c, d. On a follow-up CT scan of the chest performed 2 months after A and B, previously noted peripheral consolidative opacities and GGO were mostly resolved, in response to corticosteroid therapy (c). However, a new focus of peripheral consolidation with surrounding GGO was noted in the right lower lobe (white arrow, d) outside of the irradiated lung field. e, f. Further follow-up CT taken 1.5 months after Fig. c and d demonstrated resolving peripheral consolidation that appeared on Fig. D noted as residual GGO (white arrow, f); however, additional new foci of peripheral consolidation with surrounding GGO are noted both outside of the radiation field (white arrows, e) and within the irradiated lung (black arrows, e, f)

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