Immunosuppression at initiation of checkpoint inhibitor therapy | Allograft rejection, no./reported cases (%) | Tumor responsea, no./reported cases (%) |
---|---|---|
All patientsb | 15/38 (40) | 15/32c [47] |
Single-agent immunosuppressive therapy | ||
Prednisone (≤10 mg/day) | 7/9 (78) | 5/8 (63) |
mTOR inhibitors | 2/3 (67) | 1/2 (50) |
Calcineurin inhibitors | 1/9 (11) | 2/8 (25) |
Combination immunosuppressive therapy | 5/17 (29) | 7/14 (50) |