Fig. 2
From: Automated image analysis of NSCLC biopsies to predict response to anti-PD-L1 therapy
Predictive value of the CD8xPD-L1 signature compared to individual components. The comparative values are demonstrated by Kaplan-Meier analysis for overall survival of the durvalumab-treated patient test set for CD8xPD-L1 signature (a), CD8+ cell density (b), programmed cell death ligand-1 (PD-L1) + cell density (c), and manual pathologist scoring of PD-L1 tumor cell expression (d). Kaplan-Meier curves show survival probability, with shaded areas representing 95% confidence intervals. The cutoff values by which each measure was determined positive or negative were 1.54 × 105 cells2/mm4 for CD8xPD-L1 signature positivity; 297 cells/mm2 for CD8+ tumor infiltrating lymphocyte density; and 644 cells/mm2 for PD-L1+ cell density. The cutoff value for PD-L1 manual scoring, ≥25% tumor cells, was determined previously [39]