Fig. 4
From: Automated image analysis of NSCLC biopsies to predict response to anti-PD-L1 therapy
The prognostic values of CD8+ tumor infiltrating lymphocyte (TIL) densities and programmed cell death ligand-1 (PD-L1) measures. These are demonstrated by Kaplan-Meier analysis for overall survival by CD8+ (a) and PD-L1+ (b) cell densities and manual pathologist scoring of PD-L1 tumor cell expression (c) in patients who did not receive immune checkpoint therapy. Kaplan-Meier curves show survival probability, with shaded areas representing 95% confidence intervals. The cutoff values by which each measure was determined positive or negative were 297 cells/mm2 for CD8+ TIL density and 644 cells/mm2 for PD-L1+ cell density. The cutoff value for PD-L1 manual scoring, ≥25% tumor cells, was determined previously [39]