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Table 2 Multiparametric Cox analysis of predictive signatures (test set)

From: Automated image analysis of NSCLC biopsies to predict response to anti-PD-L1 therapy

Significant fixed covariate

Significance [fixed covariate]

Added covariate

Significance [added covariate]

Significance [Cox Model]

None

N/A

None

N/A

–

LM

+

PD-L1 expression

–

–

None

N/A

CD8+ cell density

+

–

LM

+

PD-L1+ cell density

+

–

None

N/A

CD8xPD-L1 signature

+++

++

  1. The parameters shown represent an analysis performed on the test set of durvalumab-treated patient tumor samples. Fixed covariates at baselines were histology, smoking status, age, gender, liver metastasis, tumor stage and line of therapy. - > 0.05; + ≤ 0.05; ++ ≤ 0.005; +++ ≤ 0.0005
  2. Abbreviations: CD8 Cluster of differentiation 8, LM Liver metastasis, N/A Not applicable, PD-L1 Programmed cell death ligand-1
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