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Table 2 Multiparametric Cox analysis of predictive signatures (test set)

From: Automated image analysis of NSCLC biopsies to predict response to anti-PD-L1 therapy

Significant fixed covariate Significance [fixed covariate] Added covariate Significance [added covariate] Significance [Cox Model]
None N/A None N/A
LM + PD-L1 expression
None N/A CD8+ cell density +
LM + PD-L1+ cell density +
None N/A CD8xPD-L1 signature +++ ++
  1. The parameters shown represent an analysis performed on the test set of durvalumab-treated patient tumor samples. Fixed covariates at baselines were histology, smoking status, age, gender, liver metastasis, tumor stage and line of therapy. - > 0.05; + ≤ 0.05; ++ ≤ 0.005; +++ ≤ 0.0005
  2. Abbreviations: CD8 Cluster of differentiation 8, LM Liver metastasis, N/A Not applicable, PD-L1 Programmed cell death ligand-1