Fig. 2
From: STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia
Constitutive calcium entry (CE) is independent from anti-IgM capacity to induce Ca2+ signaling in chronic lymphocytic leukemia (CLL). a- Normalized ratio of peak to baseline Ca2+ flux in response to anti-IgM stimulation of healthy control (n = 13, Ctrl), CE- CLL (n = 13) and CE+ CLL (n = 16) samples. b- Bivariate analysis by Kaplan-Meier curves of Ca2+ signaling in the context of CLL subsets according to the CE (+/−) and anti-IgM capacity to induce Ca2+ signaling (IgM +/−). A Cox regression model of progression free survival (PFS) was used to dichotomize CLL patients in CE- and CE+, on one hand, and IgM- and IgM+, on the other hand. c/d- the effects of Ibrutinib (BTK inhibitor, 2.5 μM) and LY294002 (PI3K inhibitor, 5 μM) on CE in CE+/IgM+ B-CLL samples (n = 3). e/f- the effects of Ibrutinib (BTK inhibitor) and LY294002 (PI3K inhibitor) on anti-IgM capacity to induce Ca2+ signaling in CE+/IgM+ B-CLL samples (n = 3). P values are indicated when significant