Fig. 1

Effect of C + P on tumor size and E7LP vaccination. Groups of female mice bearing TC-1 genital tumors received i.p. 1 dose of Carboplatin (40 mg/kg) at day 8 and 2 doses of paclitaxel (20 mg/kg at days 8/9 and/or s.c. vaccination with E7 vaccine (E7LP) at day 13. Mice survival (a) and tumor luminescence before vaccination (b) are shown. C: Flow-cytometry analysis of TC-1 genital tumors untreated or treated with C + P as indicated on the graphs is shown at day 13. Individual and mean % among CD45⁺ of myeloid cells (CD45⁺CD11b⁺), gMDSC (CD45⁺CD11b⁺Ly6G⁺), mMDSC (CD45⁺CD11b⁺Ly6C⁺) and macrophages (CD45⁺CD11b⁺Ly6G⁻Ly6C⁻F4/80⁺) are shown. Significant differences are shown following a log rank test (a) or a Student t-test (b-c): * = p < 0.05, ** = p < 0.01, *** = p < 0.001, **** = p < 0.0001