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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Carboplatin/paclitaxel, E7-vaccination and intravaginal CpG as tri-therapy towards efficient regression of genital HPV16 tumors

Fig. 2

Intravaginal (ivag) immunostimulation with CpG after C + P and E7LP vaccination resulted in an effective tri-therapy. Groups of female mice bearing TC-1 genital tumors received different treatments as indicated on the graphs. C + P (days 8/9) and/or vaccination with E7LP (day 15) and /or ivag administration of CpG (at days 20, 23 and 26). Tumor luminescence before vaccination or before ivag CpG (a), percentages of tumor free mice before ivag CpG (b) and after ivag CpG (days 26–29) (c) and mice survival (d) are shown. Total number of mice/group (n) are indicated (b-c). Significant differences following one-way Anova +Tukey’s post-test (a), contingency Chi-square test (b-c) or log rank test (d) are shown: * = p < 0.05, ** = p < 0.01, *** = p < 0.001, **** = p < 0.0001

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