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Table 1 Geographical pattern of immune checkpoint inhibitor-related haemophagocytic lymphohistiocytosis reporting rate

From: Haemophagocytic lymphohistiocytosis in patients treated with immune checkpoint inhibitors: analysis of WHO global database of individual case safety reports

Country of primary source

Total number of

ICI-related safety reports

Number of ICI-related HLH safety reports

ICI-related HLH reporting rate (%)

France

3526

14

0.4

Japan

6421

11

0.2

Germany

1901

3

0.2

Switzerland

830

1

0.1

Canada

1279

1

0.08

US of America

24'998

8

0.03

  1. Abbreviations: ICI immune checkpoint inhibitor, HLH haemophagocytic lymphohistiocytosis