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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Anti-pancreatic tumor efficacy of a Listeria-based, Annexin A2-targeting immunotherapy in combination with anti-PD-1 antibodies

Fig. 1

Construction of Lm-ANXA2 and treatment with Lm-ANXA2 improves survival in a PDAC mouse model. a Schematic diagram of the LADD strain with the Annexin A2 expression cassette. b Western blot analysis of DC2.4 cells infected by Empty Lm and Lm-ANXA2. Top panel: blot with an anti-ActA antibody detecting the ANXA2 fusion protein; bottom panel: blot with anti-Listeria P60 protein as an infection and loading control. Molecular weight showed on the left. c Kaplan-Meier survival curves of mice that were implanted with PDAC cells and were untreated (n = 5) or treated with either Empty Lm (n = 13) or Lm-ANXA2 (n = 13). A representative of three repeated experiments is shown

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