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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Anti-pancreatic tumor efficacy of a Listeria-based, Annexin A2-targeting immunotherapy in combination with anti-PD-1 antibodies

Fig. 2

Listeria based Immunotherapy with concomitant CD8+ T cell depletion. Mice implanted with KPC PDAC cells on day 0 underwent treatment with Lm-ANXA2 as described (n = 10–12 mice per group). CD8+ depletion was started on day 2 via anti-CD8a antibody (10 mg/kg IP; 2.43, BioXcell) until day 30. Kaplan-Meier curves reveal survival in PDAC bearing mice treated with Lm-ANXA2 and CD8+ T cell depletion is significantly shorter than that of mice treated with Lm-ANXA2 without CD8+ T cell depletion (p = 0.027)

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