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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop

Fig. 2

The tumor-immune microenvironment consists of a variety of cell types. All cell types comprise different transcriptional profiles. The top depicts all major categories of cell types present in a TME with a color code indicating their overall predictive value for immune responsiveness (red more responsive; blue less responsive). Some transcriptional alterations impacting immune responsiveness are highlighted beneath. The middle depicts a tumor and a subset of immune cells found within a TME and represents the challenge transcriptional profiling is facing right now. The bottom depicts the ultimate goal – using transcriptional profiling of whole tumor or single cells of the TME to predict immune responsiveness

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