Fig. 1

Clinical response following initiation of avelumab in patients with recurrent respiratory papillomatosis. a, A spider plot of change in laryngeal disease burden for each patient, as measured by anatomic Derkay score, is shown. The dotted line shows the time that avelumab was initiated. The negative time points reflect screening assessments prior to starting treatment. Patients 5, 7, 8, 9 and 11 received 6 doses of avelumab over 12 weeks. Patients 1, 2, 3, 4, 6, 10 and 12 received three doses over 6 weeks. b, Representative endoscopic images of RRP lesions for patients 5, 6 and 9 at the timepoints indicated are displayed. c, A spider plot of the change in pulmonary disease burden for each patient, as measured by CT scan imaging per RECIST1.1 guidelines, is shown. d, Representative images from CT scans from patients 6, 10 and 11 are displayed. Red arrows point to index lesions